Nuclear actions of insulin-like growth factor binding protein-3
نویسندگان
چکیده
منابع مشابه
Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3.
BACKGROUND A recent report suggested that men with vertex balding have higher levels of plasma insulin-like growth factor 1 (IGF-1). The association of its major carrier protein, insulin-like growth factor binding protein 3 (IGFBP-3), with male pattern hair loss has not been examined. OBJECTIVE We evaluated the relations of plasma concentrations of IGF-1 and IGFBP-3 with vertex balding in mid...
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In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may inhibit mitogenesis, differentiation, survival, and other IGF-stimulated events. IGFBP proteolysis can reverse this inhibition or generate IGFBP fragments with novel bioactivity. Alternatively, IGFBP interacti...
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Plasma levels of insulin-like growth factor I (IGF-I) have been associated with risk of several cancers. Although protein-calorie malnutrition is known to decrease IGF-I levels, few published studies have related diet to IGF-I levels in well-nourished humans. We examined the cross-sectional association of plasma IGF-I and IGF-binding protein 3 (IGFBP-3) levels with intakes of alcohol, energy, m...
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ژورنال
عنوان ژورنال: Gene
سال: 2015
ISSN: 0378-1119
DOI: 10.1016/j.gene.2015.06.028